Original Research Article
Year: 2014 | Month: January | Volume: 4 | Issue: 1 | Pages: 85-92
In Vitro Activity of Tigecycline against Multidrug Resistant Gram Negative Bacilli as Evaluated by Disc Diffusion Method and E-Test
Manisha Mane1*@, Nita Gangurde2*, Sunita Phatale2**
*Associate Professor,**Assistant Lecturer,
1Dept of Microbiology, ESIC MC & PGIMSR, K K Nagar, Chennai-600078, Tamil Nadu, India
2Dept of Microbiology, Dr V.P. Medical College & Hospital, Nashik, Maharashtra-422003, India
@Corresponding Author: Manisha Mane
ABSTRACT
Introduction: Tigecycline is an antibiotic belonging to the glycylcyclines class with in vitro activity against most gram negative bacteria, even multidrug resistant pathogens. It is considered to be a newer treatment option for emerging multidrug resistant pathogens.
Objectives: To evaluate the in vitro activity of tigecycline against Multidrug resistant gram negative bacteria isolated from various clinical specimens to compare with other antimicrobials.
Materials & methods: A total of 150 multidrug resistant isolates of Enterobacteriaceae (113) and Acinetobacter spp (37) were tested for tigecycline susceptibility by the E-test and disc diffusion method.
Results: Tigecycline showed good microbiological activity against all the isolates of multidrug resistant gram negative bacteria with 100% susceptibility in E. coli & Enterobacter species, 94% in Klebsiella species and 81.08% in Acinetobacter spp. isolates.
Conclusion: Tigecycline was found to be highly effective against multidrug resistant gram negative bacteria. Therefore it is an alternative option for treatment of complicated skin &soft tissue and intra-abdominal infections caused by such multidrug resistant pathogens.
Key words:Tigecycline, multidrug resistance (MDR), in vitro susceptibility, ESBL, MBL