Original Research Article
Year: 2019 | Month: June | Volume: 9 | Issue: 6 | Pages: 285-292
Effect of a Combined Nutraceutical Supplement on the Lipid Profile of Hypercholesterolemic Men
Geetha. S1, Kalaivani Ashok. C2
1Assistant Professor- Department of Home Science- Nutrition, Food Service Management and Dietetics, SDNB Vaishnav College for Women, Chrompet, Chennai-600044, (Tamilnadu) India.
2Associate Professor- Department of Home Science, Queen Marys College, Mylapore, Cheenai-600004, (Tamilnadu) India.
Corresponding Author: Kalaivani Ashok. C
ABSTRACT
BACKGROUND: The prevalence of hypercholesterolemia is on the rise in India. Hypercholesterolemia is implicated in the development of coronary heart disease. Current projections suggest that one fifth of the deaths in India are due to coronary heart disease. Evidence point to nutraceutical supplements with a hypocholesterolemic effect as capable of reducing the risk of coronary heart diseases.
AIM & OBJECTIVE: To examine the hypocholesterolemic effect of nutraceuticals an investigation was undertaken to determine the effectiveness of a combined nutraceutical supplement on hypercholesterolemic men.
MATERIALS AND METHODS: A pre-test, post-test experimental research design was used in this study. First screening for hypercholesterolemia was done on 90 males between 25-60 years. After screening, a purposive sample of 40 males having borderline hypercholesterolemia above 200mg/dl and below 240mg/dl, with a cardiovascular risk ratio above 4.5 were chosen for the study, The participants were included in the study after obtaining their consent to participate in the study. Out of the subjects chosen 20 were randomly assigned to the experimental group and administered the combined nutraceutical supplement which contained curcumin, lycopene, lutein and proanthocyanidin twice a day for a period of 60 days. The remaining 20 subjects who were in the control group did not receive any supplement. Fasting blood samples were collected from all the subjects both on the1st and 60th day for estimation of lipid profile. Paired t-test was used to compare the changes in the lipid profile between and within groups, p-value<0.05 was considered as significant.
RESULT: At baseline, both the experimental and control groups were similar with respect to anthropometric and lipid parameters. The experimental group showed significant reductions in levels of VLDL(mg/dl), triglyceride(mg/dl) and CHO/HDL with a concomitant increase in HDL(mg/dl) as compared to the control group. Total cholesterol (mg/dl), LDL(mg/dl), CHO/HDL levels decreased significantly in the experimental group after 60 days of supplementation with the combined nutraceutical supplement as compared to the initial levels.
CONCLUSION: The results of the study endorse the lipid lowering properties of the combined nutraceutical supplement.
Key words: Nutraceutical, hypercholesterolemia, Lipid profile.