Review Article
Year: 2019 | Month: February | Volume: 9 | Issue: 2 | Pages: 241-250
Role of Lipid Peroxidation in Diabetic and Senile Cataract - A Review
G. Swathy1, Suhas Prabhakar2, C. Umamaheswara Reddy3, C. K. Dhanapal 4
1Research Scholar, Dept of Pharmacology, Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education & Research, Chennai, India
2Prof & Head, Department of Ophthalmology, Sri Ramachandra Institute of Higher Education & Research, Chennai, India
3Prof & Head, Dept of Pharmacology, Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education & Research, Chennai, India
4Associate Professor, Department of Pharmacy, Annamalai University, Annamalai Nagar- 608002
Corresponding Author: Suhas Prabhakar
ABSTRACT
The association of lipids in cataract has been discussed for about two centuries and lipid peroxidation is identified as the inceptive stage, causing lipid-lipid and lipid-protein interactions which lead to lens opacity causing cataract. Reactive oxygen species play a significant role in lipid oxidation and forms byproducts by reacting with lipids. Worldwide blindness due to cataract is increasing steadily and diabetes patients are more prone when compared to non-diabetic patients. With the advancement in surgical procedures, there exist postoperative and intraoperative complications with higher risk in ocular co-morbid conditions, thus identifying the exact pathomechanism can pave the way for alternative treatment. This review focuses on lipid peroxidation products that play an essential part in opacification of the lens. The present study gives an insight of lipids in the cataract of diabetic and non-diabetic patients concerning the presence of their byproducts in plasma, lens tissue and aqueous humor.
Key words: Senile cataract, diabetes mellitus, lipid peroxidation