Original Research Article
Year: 2019 | Month: February | Volume: 9 | Issue: 2 | Pages: 1-5
Association of Histopathological Grading Of Oral and Oropharyngeal Cancers and Its Correlation with Tobacco Abuse both Smoked and Non-Smoked In Western Part of Uttar Pradesh: A Hospital Based Study
Debashis Panda1, Santanu Chaudhuri2, Sanjeev K Gupta3, Neeraj Kumar1, Saurabh Goswami1, Mamta Sharma4, Suchi Mittal5, Navin Kumar6
1Attending Consultant, Department of Clinical Oncology, Nayati Healthcare and Research Centre, Mathura, India-281003.
2Chairman, Centre of Excellence for Oncology, Nayati Healthcare and Research Centre, Mathura, India-281003.
3Consultant, Department of Clinical Oncology, Nayati Healthcare and Research Centre, Mathura, India-281003.
4Attending Consultant, Department of Biostatistics, Nayati Healthcare and Research Centre, Mathura,
India-281003.
5Consultant, Department of Pathology, Nayati Healthcare and Research Centre, Mathura, India-281003.
6Biostatistician, Department of Biostatistics, Nayati Healthcare and Research Centre, Mathura, India-281003.
Corresponding Author: Dr Santanu Chaudhuri
ABSTRACT
Introduction: Overall 95% of oral and oropharyngeal cancers are caused by tobacco consumption. Squamous cell carcinoma is the most common histopathology in these sites. Histopathologically these cancers can be grade 1, grade 2 and grade 3. Here we have tried to correlate the association of these histopathology grades with tobacco chewing habits in western part of Uttar Pradesh, India.
Material and methods: This is a retrospective cross-sectional hospital based study, performed in Nayati Health Care and Research Centre, Mathura, Uttar Pradesh. Total 40 subjects who were tobacco users with histopathologically proven squamous cell carcinoma of oral and oropharyngeal malignancies, registered in our hospital between Jan 2017 and July 2018, included in our study. Fisher’s Exact Test used for categorical variables to see the association between them.
Results: The most common age groups affected by oral and oropharyngeal malignancies were 51-60 (32.5%) followed by 61-70 years (25%). Male (87.5%) preponderance was observed. 70% cases were of oral cavity and 30% oropharyngeal cancers. It was observed that 82.5% cases presented in stage III and IV. Grade 2 was more common (65%) followed by grade 1 (25%). There was statistically significant association between grade and male gender [p=0.04] and no significant association observed between grade and tobacco habits.
Conclusion: Thus, we can conclude that though tobacco acts as a risk factor in oral and oropharyngeal malignancies, still it cannot be certainly concluded that tobacco habits could be associated with the grade of the disease, which is a major prognostic factor.
Key words: Oral and oropharyngeal malignancies, histopathological grade, tobacco abuse.