Original Research Article
Year: 2019 | Month: January | Volume: 9 | Issue: 1 | Pages: 42-45
Incidence of Bone Marrow Infiltration and Hematological Profile in Patients of Neuroblastoma- A Tertiary Care Experience
Dr Sanjay Mishra1, Dr Mili Jain1, Dr Atin Singhai2, Prof A K Tripathi3, Prof Ashutosh Kumar4, Prof U S Singh5
1Assistant Professor, 2Associate Professor, 4Professor and Head, 5Professor,
Department of Pathology, King George's Medical University, Lucknow, Uttar Pradesh, India
3Professor and Head, Department of Clinical Hematology, King George's Medical University, Lucknow, Uttar Pradesh
Corresponding Author: Dr Sanjay Mishra
ABSTRACT
Introduction: Neuroblastoma is one of the commonest malignancies of infancy. The clinical presentation of neuroblastoma is very heterogeneous and depends on the stage of disease. Bone marrow infiltration occurs in approximately 50% of the patients at presentation and the procedure can be used in staging of disease. Bone marrow aspiration and biopsy can therefore be utilized as a good method for staging of disease in under resourced laboratories.
Materials and Methods: The patients suffering from proven neuroblastoma by Histopathology and Immunohistochemistry were included in the study. Bone marrow aspiration and biopsy from posterior superior iliac spine was performed in these patients. Only new cases were included in the study.
Result: Total number of 45 patients was enrolled in the study. The study group belonged to age group of 05 months to 18 years. Most common site of involvement was of adrenal medulla. In our study bone marrow infiltration was seen in 53.3% of patients. The predominant pattern of infiltration was diffuse pattern with rosette formation at places. Anaemia was the commonest manifestation (87.5%)
Conclusion: Neuroblastoma is clinically heterogeneous disease with clinical spectrum ranging from asymptomatic individuals to highly symptomatic individuals. The prognosis depends a lot on the stage of disease. Bone marrow aspiration and biopsy is one of the simplest methods of staging the disease in under resourced hospitals.
Key words: Neuroblastoma, Bone marrow aspiration and biopsy, Adrenal medulla, malignancy