Original Research Article
Year: 2019 | Month: December | Volume: 9 | Issue: 12 | Pages: 232-237
Evaluation of the Survival of Children Infected With HIV Followed for 10 Years at the Pediatric Hospital of Kalembe-Lembe in Democratic Republic of Congo
Mupuala Masaya Aimée1, Paul De Cock2, Nkodila Natuhoyila Aliocha3, Nsibu Ndosimao Célestin1, Annelies Van Rie4, Tady Muyala Bempui Bruno Paul1
1Department of Pediatric, University Clinics of Kinshasa, DR Congo
2COS, KU-Leuven, Belgium
3 Medical Center of Cité des Aveugle, DR Congo
4Department of Epidemiology, The University of North Carolina at Chapel Hill.
ABSTRACT
The causes of decreased survival of HIV children are dominated by immunosuppression in developing countries. But data on survival in sub-Saharan Africa are fragmentary. The overall goal was to assess the survival of HIV-infected children at Kalembe-Lembe Pediatric Hospital.
A prospective cohort study of HIV-infected children followed at the Kalembe-Lembe Pediatric Hospital between 2006 and 2015. Death was the criterion of judgment and children lost to follow-up were censored. The curves of Kaplan Méier made it possible to describe the survival of children at the threshold of p <0.05.
Thirty-five children, including 20 girls (57.1%), median age 45.7 months, 22.9% at WHO stage 4 and 60% with psychomotor delay were included. 48.6% of the children had died. The probability of survival was 74.3% at 1 year, 68.6% at 2 years, 54.3% at 4 years, at 51.4% at 6 years and 45.7% at 10 years. The median survival time was 6 years (IEQ: 4.7-7.4). Stage 4 WHO, CD4 cell count <200 cells/μL, and psychomotor delay reduced the survival of HIV-infected children.
Decreased immunity in children and mental retardation are the poor prognostic factors for child survival in this cohort. Screening, early initiation of HART, and the fight against the retardation mental can increase the survival of children infected with HIV.
Key words: Survival, Infected children, HIV, Psychomotor retardation, Kalembe-Lembe Pediatric Hospital