Case Report
Year: 2019 | Month: November | Volume: 9 | Issue: 11 | Pages: 111-114
Primary Diffuse Laryngeal Amyloidosis, a Rare Cause of Hoarseness of Voice
Dr. Anmol Wadhwa1, Dr. Yogesh G. Dabholkar2, Dr. Bhavika Verma Bhatt3, Dr. Akanksha Saberwal4, Dr. Haritosh K. Velankar5
1Junior resident, 2Professor and Head, 3Senior Resident, 4Assistant Professor, 5Professor,
Department of ENT Dr. D.Y. Patil School of Medicine, Navi Mumbai,
Corresponding Author: Dr. Anmol Wadhwa
ABSTRACT
Introduction: Amyloidosis is a heterogenous group of disorders characterised by deposition of amyloid proteins in various body organs. Of the numerous types, Laryngeal Amyloidosis is an extremely rare disease of unknown etiology.
Case report: We report a case of 30 year old woman who presented with hoarseness of voice and stridor necessitating a tracheostomy to secure the airway. A diagnosis of isolated laryngeal amyloidosis was made based on histopathology and thorough clinical and laboratory workup, and the patient responded to a combination therapy of oral corticosteroids and Bortezomib.
Conclusion: Laryngeal amyloidosis is a rare disease, and its diagnosis calls for a high index of suspicion as well as thorough workup to exclude systemic involvement.
Key words: Larynx, amyloidosis, diffuse, hoarseness, stridor, bortezomib