Original Research Article
Year: 2017 | Month: June | Volume: 7 | Issue: 6 | Pages: 108-115
Role of Hormones, Body Mass Index & Fasting Blood Glucose Levels in Amenorrhea Cases
Dr. V. Rajitha1, Dr. G. Rekha1, Dr. K. Y. Manjunath2, Dr. S. Senthil Nathan3
1Assistant Professor, Department of Anatomy, Vinayaka Missions Kirupanandavariyaar Medical College, Salem. Tamil Nadu
2Professor, Department of Anatomy, Annapoorna Medical College and Hospital, Salem.
3Associate professor, Department of Radiology Annapoorna Medical College and Hospital, Salem.
Corresponding Author: Dr. V. Rajitha
ABSTRACT
Introduction: Absence of menstruation is termed as amenorrhea prevalence of primary amenorrhea in India is higher when compared with worldwide prevalence with a potential social impact and due to higher prevalence of amenorrhea in Indian society; extensive evaluation is required to overcome the anxiety.
Aims: 1) To identify the average age of attainment of menarche in secondary amenorrhea. 2) To evaluate role of body mass index in the regulation of menstrual cycles. 3) To estimate serum hormonal levels in subjects of primary and secondary amenorrhea and their variation with that of control group. 4) To estimate fasting blood glucose levels and its correlation with amenorrhea in comparison with control group.
Materials and Methods: This study was performed on 200 women volunteers with detail history, parameters like body mass index (BMI), hormonal levels and fasting blood glucose (FBG) were estimated.
Results: Based on diagnosis the study group number of Primary amenorrhea (PA) (n=8), Secondary amenorrhea with unknown etiology (SA) (n=6), Polycystic ovarian disease (PCOD) (n=82) and Premature ovarian failure (POF) (n=4). The mean value of FSH among cases was12.78 ± 20.6 mIU/ml and the mean value of FSH among controls was 5.31± 3.43 mIU/ml. The mean values of LH among cases and controls were 6.58 ± 4.40 mIU/ml and 4.67 ± 3.11mIU/ml respectively. The value of ratio of FSH:LH was more than 2 in 29% of the cases and among 7% of the controls. The mean value of FBG levels in cases was 96.04±18.56, and in controls was 84.05±7.03.
Conclusion: In present study obesity has a direct effect on the menstrual cycle of the women leading to amenorrhea. The levels LH and FSH were above the normal limits in women with primary amenorrhea in our study and the ratio between the hormones was also high. FBG levels were found to be very high among amenorrhea patients when compared with controls this proves prevalence of high insulin resistance among females with menstrual irregularities
Key words: Amenorrhea, Follicular Stimulating Hormone (FSH), Luteinizing hormone (LH), Thyroid stimulating hormone (TSH), Body mass index (BMI), Fasting blood glucose levels (FBG)