Original Research Article
Year: 2016 | Month: October | Volume: 6 | Issue: 10 | Pages: 10-15
Assessment of Efficacy and Safety of Intravenous Iron Sucrose Compared to Oral Iron Sulphate Therapy in Anemia among Antenatal Women Visiting Primary Health Centres, District Ambala, Haryana
Arvinderjeet Singh1, RKD Goe2, Anu Bhardwaj3, Anshu Mittal3, Zahid Ali Khan4, Sh. Parmal Saini4, Kshitij Choudhary1
1PG-Final, 2Professor & Head, 3Professor, 4Assistant Professor,
Department of Community Medicine, MMIMS & R Mullana, Ambala.
Corresponding Author: Arvinderjeet Singh
ABSTRACT
Background: Anemia is the most common disorder of the blood, affecting a quarter of the world’s population globally. WHO defines anemia as hemoglobin level (HB) <11g/dl in pregnancy. In India, prevalence of anemia ranges between 33%-89%. About half of the global maternal deaths due to anemia occur in south Asian countries; India contributes to about 80% of this mortality ratio.
Objectives: 1) To compare the efficacy of intravenous iron sucrose with oral iron sulphate therapy to treat anemia in pregnant women visiting the Primary Health Centers of Ambala District, Haryana.
2) To evaluate the side effects and complications of Intravenous Iron Sucrose and Oral Iron Sulphate therapies in these patients.
Sample size: A total of 400 (rounded) 200 antenatal cases for intravenous therapy and 200 for oral sulphate therapy.
Materials and Methods: A community based prospective study was conducted and all eligible Antenatal females (20-24 weeks of gestation) visiting Primary Health Centers and with hemoglobin level 7.1-8.9 g/dl, having received IV Iron sucrose or Oral Iron sulphate therapy were evaluated. Results: The target haemoglobin was achieved in 37.0% antenatal women in Group A whereas only 12% achieved the target haemoglobin in Group B. 14.5% of the Intravenous group A had side effects as compared to 25.4% of Oral group B (p=0.009).
Conclusion: This study concluded that intravenous iron sucrose is safe and highly efficacious for the treatment of iron deficiency anemia in pregnancy as compared to oral iron sulphate therapy.
Key words: Intravenous iron sucrose, iron deficiency anemia, oral iron sulphate, antenatal.