Original Research Article
Year: 2016 | Month: October | Volume: 6 | Issue: 10 | Pages: 96-104
Serum Inorganic Phosphate Concentration and Glycated Haemoglobin Percent in Type 2 Diabetes Mellitus - A Hospital Based Study
Girindra Kr. Bora1*, Rashmi Rajkakati2**, Sanjeeb Kakati3***, Sushma Yadav1*
1Demonstrator, 2Associate professor, 3Professor,
*Department of Biochemistry, Jorhat Medical College, Jorhat-785001, Assam, India.
**Department of Biochemistry, Assam Medical College, Dibrugarh-786002, Assam, India.
***Department of Medicine, Assam Medical College, Dibrugarh-786002, Assam, India.
Corresponding Author: Girindra Kr. Bora
ABSTRACT
Objective:
1. To study serum inorganic phosphate concentration and glycated hemoglobin percent in patients with type 2 diabetes mellitus.
2. To find the correlation between serum inorganic phosphate level and glycated hemoglobin level in patients with type 2 diabetes mellitus.
Materials and methods: The study was carried out on 50 newly diagnosed patients of type 2 diabetes and controls in the Department of Biochemistry, Assam medical college, Dibrugarh. Analysis of blood glucose (fasting and postprandial), HbA1c, serum inorganic phosphate, urea and creatinine concentrations were performed by standard methods using semi automated analyser.
Results: Concentrations of fasting and postprandial blood glucose higher in the diabetic group than controls (p<0.01), and the mean HbA1c% was also higher in cases (8.82±1.66%). The mean serum inorganic phosphate concentration in cases was found to be significantly lower than controls (2.68±0.56 vs 3.64±0.42 mg/dl) and p < 0.01. Present study revealed an inverse relationship between serum inorganic phosphate concentration and HbA1c% in patients with type 2 DM with a correlation coefficient, r = - 0.81 substantiated by regression analysis.
Conclusion: There is definite reduction of serum inorganic phosphate concentration in type 2 DM patients and that reduction of serum inorganic phosphate concentration may have a contributing role in the progression of the disease and development of complications of diabetes.
Key words: diabetes, inorganic phosphate, glycated hemoglobin.