Original Research Article
Year: 2016 | Month: October | Volume: 6 | Issue: 10 | Pages: 91-95
Diabetic Dyslipidemia Insulin Resistance May Be One of the Causes of Microalbuminuria
Mahendra D. Bikkad, Suresh S. Ugle
Department of Biochemistry, MIMSR Medical College Latur, India.
Corresponding Author: Suresh S. Ugle
ABSTRACT
Background and Objectives: The first clinical sign of renal dysfunction (nephropathy) in patients with diabetes generally is microalbuminuria (a sign of endothelial dysfunction that is not necessarily confined to the kidney). The present epidemic of diabetes is significantly increased by growing problems of lifestyle changes, faulty nutrition, obesity etc. The aim of our study was to know the occurrence of microalbuminuria in patients with type 2 diabetes mellitus and to study its relation with diabetic dyslipidemia and insulin resistance.
Methodology: The study was undertaken in MIMSR Medical College Latur. A total number of 50 type 2 diabetes mellitus patients and 50 healthy subjects satisfying the inclusion criteria were selected for study. The lipid profile, urinary microalbumin and creatinine, were determined and compared.
Results: In the control group 1 the mean values of total cholesterol were 173.92± 26.83 mg%, triglycerides 100.102±24.71 mg%, LDL-c were 106.67±27.82 mg%, HDL-c were 45.31±3.58 mg%, VLDL-c were 18.50±4.29 mg%, TG/HDL-c ratio were 2.05±0.46 mg%, urinary microalbumin were 7.20±31.95 mg/L and urinary creatinine were 3.64±4.5Mmol/L. In the group 2 the mean values of total cholesterol were 183.182±42.60 mg%, triglycerides 156.082±61.44mg%, LDL-c were 117.05±33.65mg%, HDL-c were 41.67±3.5mg%, VLDL-c were 31.64±11.63mg%, TG/HDL-c ratio were 3.81±1.3 mg%, urinary microalbumin were 78.60±41.89 mg/L urinary creatinine were 5.28±4.81Mmol/L. The serum triglycerides and TG/HDL-c ratio and urinary microalbumin in group 2 were significantly increased as compared to the group 1. The HDL-c in group 2 was significantly decreased as compared to the group 2.
Conclusion: The occurrence of microalbuminuria in type 2 diabetes patients in this study was significantly influenced by the dyslipidemia especially hypertriglyceridemia (TG/HDL-C ratio above three). The importance to lipid profile correction particularly to lower TG and increases HDL-C (to remove insulin resistance) has to be stressed, as it will help in better glycemic control and reduction to nephropathy.
Key words: Type 2 diabetes, dyslipidemia, insulin resistance, microalbuminuria, and nephropathy.