Year: 2026 | Month: August | Volume: 16 | Issue: 8 | Pages: 74-83
DOI: https://doi.org/10.52403/ijhsr.20260808
Uterine Lipoleiomyoma: A Case Series of Five Patients from a Tertiary Care Centre
Kanwardeep Kaur1, Ramandeep Kaur2, Tanya Aggarwal3, Shefali Gupta4, Karitika Aggarwal5
1Associate Professor, 2Assistant Professor, 3,4,5Junior Resident,
Department of Pathology, Government Medical College and Rajindra Hospital, Patiala, Punjab, India
Corresponding Author: Dr. Ramandeep Kaur
ABSTRACT
Uterine lipoleiomyoma is a rare benign variant of uterine leiomyoma characterised by an admixture of mature adipose tissue and smooth muscle cells, with a reported incidence ranging from 0.03% to 0.2%. It predominantly affects postmenopausal women and is most commonly located in the uterine corpus. We report a case series of five patients with uterine lipoleiomyoma: two cases identified prospectively during a one-year audit of hysterectomy specimens, and three additional cases retrieved from institutional records that broaden the observed clinicopathological spectrum. Patients ranged in age from 49 to 70 years (mean 57.4 years) and presented with pelvic pain or heaviness, abnormal uterine bleeding, urinary frequency, or progressive abdominal distension. Tumour location included the uterine corpus (intramural, submucosal, and subserosal) and, in one case, the cervical stroma; tumour size ranged up to 14 × 12 × 10 cm, consistent with the rare ‘giant’ variant. One perimenopausal patient with a submucosal tumour was managed by fertility-sparing myomectomy; the remaining four underwent hysterectomy with bilateral salpingo-oophorectomy. Gross examination in all cases revealed well-circumscribed, yellow to yellow-white masses with a whorled cut surface. Histopathological examination demonstrated the characteristic admixture of mature adipocytes and benign smooth muscle bundles without cytological atypia, lipoblasts, or necrosis in every case, with hyaline, myxoid, or dystrophic calcific change noted focally in three cases. All patients had an uneventful postoperative course. This series illustrates the diverse ages, tumour locations, and management strategies encountered in uterine lipoleiomyoma and reinforces the importance of recognising this entity to avoid diagnostic confusion with other adipocytic tumours of the uterus.
Key words: Lipoleiomyoma; uterine leiomyoma; adipocytes; hysterectomy; myomectomy; cervical lipoleiomyoma; giant lipoleiomyoma; histopathology; postmenopausal