Year: 2026 | Month: June | Volume: 16 | Issue: 6 | Pages: 219-228
DOI: https://doi.org/10.52403/ijhsr.20260625
Efficacy and Safety of EqualsTwo® Body Firming Cream in Lactating Postpartum Women with Cellulite: An Open-Label Single-Arm Study
Dhruv Zaveri1, Trupti Patel2, Kinjal Barot3, Parth Joshi4, Sunil S. Iyer5, M. E. Kannan5
1Senior Executive, Zydus Lifesciences Limited, Pharmaceutical Technology Centre (PTC), Sarkhej Bavla N.H. No.8A, Moraiya, Tal: Sanand, Dist.: Ahmedabad 382 210, Gujarat, India.
2Deputy General Manager, Zydus Wellness Centre, Ahmedabad 382481, Gujarat, India
3Deputy General Manager, Zydus Lifesciences Limited, Pharmaceutical Technology Centre (PTC), Sarkhej Bavla N.H. No.8A, Moraiya, Tal: Sanand, Dist.: Ahmedabad 382 210, Gujarat, India.
4Principal Investigator, Cliantha Research Limited, TP 86, FP 28/1, Off S.P. Ring Road, Sarkhej,
Ahmedabad – 382210, Gujarat, India.
5Head, Zydus Lifesciences Limited, Pharmaceutical Technology Centre (PTC), Sarkhej Bavla N.H. No.8A, Moraiya, Tal: Sanand, Dist.: Ahmedabad 382 210, Gujarat, India.
Corresponding Author: Dhruv Zaveri
ABSTRACT
Context: Cellulite causes skin dimpling and psychosocial distress. Invasive procedures and pharmacological agents offer limited, short-lived benefit. Botanical extracts improve dermal structure, circulation, and hydration.
Aims: To evaluate the efficacy and safety of EqualsTwo® body firming cream (Investigation product) containing Centella asiatica, Sacred Lotus, and Longan fruit extracts in reducing cellulite and improving skin biophysical properties in lactating mothers.
Settings and Design: Open-label, single-arm prospective trial in lactating postpartum women (infants aged 0–36 months) with stage I–III cellulite.
Methods and materials: Investigation product (4-5g) was applied to hips, buttocks, thighs, and abdomen twice daily for 12 weeks. Primary outcomes were cellulite stage/severity, skin tonicity and circumference reduction. Secondary outcomes included change in elasticity, hydration, trans epidermal water loss (TEWL), participant-reported satisfaction, and product response index.
Statistical Analysis Used: Descriptive statistics with paired comparisons; significance at P<0.0001.
Results: Fifty-four out of 60 participants completed the study. At baseline, one-third each were classified as stage I, II, or III. By day 84, 40.7% exhibited no detectable cellulite and 57.4% showed mild involvement; none remained in advanced stages. Mean reductions in circumference were 1.8 cm (thighs), 2.1 cm (buttocks), and 2.0 cm (hips) (P<0.0001). Elasticity improved 5–6%, hydration increased by 20 units, and TEWL decreased 12–13%. All participants reported improved skin clarity, and moisturization; no adverse events observed.
Conclusions: EqualsTwo® body firming cream (Investigation product) significantly reduced cellulite severity and circumference while enhancing elasticity, hydration, and barrier function in lactating mothers, demonstrating excellent safety over 12 weeks.
Key words: Botanical cream; Cellulite; Centella asiatica; Dimocarpus longan; Nelumbo nucifera; Lactating mother.