Year: 2026 | Month: January | Volume: 16 | Issue: 1 | Pages: 314-326
DOI: https://doi.org/10.52403/ijhsr.20260136
Correlation of Lipid Profile, LFT, AST/ALT Ratio, BARD, FIB-4, NFS Score, TyG Index with Transient Elastography to Detect Better Noninvasive Marker in Overweight and Obese Patient in Tertiary Care Center, West Bengal: A Cross-Sectional Observational Study
Ashis Kumar Saha1, Puja Mahato2, Aritra Kumar Ray3, Ipshita Chatterjee4, Moyukh Mukherjee5
1Head & Professor, Department of Medicine, Jagannath Gupta Institute of Medical Sciences & Hospital, Budge Budge, Kolkata
2Assistant Professor, Department of Medicine, Jagannath Gupta Institute of Medical Sciences & Hospital, Budge Budge, Kolkata
3Assistant Professor, Department of Medicine, Jagannath Gupta Institute of Medical Sciences & Hospital, Budge Budge, Kolkata, West Bengal,
4Post Graduate Trainee, Department of Medicine, Jagannath Gupta Institute of Medical Sciences & Hospital, Budge Budge, Kolkata, West Bengal
5Post Graduate Trainee, Department of Medicine, Jagannath Gupta Institute of Medical Sciences & Hospital, Budge Budge, Kolkata, West Bengal
Corresponding Author: Dr. Ashis Kumar Saha
ABSTRACT
Introduction: Metabolic associated steatotic liver disease (MASLD), previously termed NAFLD, is the most prevalent chronic liver disorder globally. It spans from simple steatosis to steatohepatitis, advanced fibrosis, and hepatocellular carcinoma. Obesity and diabetes are major contributors, while liver biopsy remains the diagnostic gold standard despite its invasiveness. Non-invasive scores and transient elastography provide alternatives, but their comparative performance in overweight and obese groups is less established.
Objectives: To assess and compare the diagnostic performance of non-invasive fibrosis scores—APRI, FIB-4, NFS, BARD score, TyG index, and AST/ALT ratio—against transient elastography in overweight and obese patients, and to identify reliable predictors of advanced fibrosis.
Materials and Methods: a retrograde cross-sectional study was carried out at Jagannath Gupta Institute of Medical Sciences & Hospital, West Bengal, involving 315 patients (220 overweight: 117 males, 103 females; 95 obese: 31 males, 64 females). Exclusion criteria included viral hepatitis, alcoholic liver disease, and autoimmune or drug-induced liver disease. Laboratory parameters, liver function tests, lipid profile, and fibrosis scores were obtained. FibroScan served as the reference. Statistical analyses included correlation, ROC curves, AUC, sensitivity, specificity, PPV, and NPV, stratified by BMI category.
Results: In overweight patients, APRI and FIB-4 showed the strongest predictive value for advanced fibrosis (AUC 0.69–0.77; NPV >90%), with NFS offering moderate accuracy. BARD and TyG index had limited utility. In obese patients, predictive accuracy declined, with APRI and FIB-4 demonstrating modest discrimination (AUC ~0.60–0.64). Male predominance was observed in overweight NAFLD, whereas females predominated in obesity.
Conclusions: APRI and FIB-4 are effective, low-cost, first-line tools for ruling out advanced fibrosis in overweight patients, while their accuracy diminishes in obese cohorts. NFS adds supplementary value, but BARD and TyG index are less useful. Transient elastography remains essential for confirmation, particularly in obesity, highlighting the role of combined approaches in clinical decision-making.
Key words: LFT, Lipid Profile, BARD Score, FIB-4, NFS score, TYG Index, Transient Elastography, Obese and Overweight Patients, Tertiary Care Center, West Bengal.