Year: 2025 | Month: September | Volume: 15 | Issue: 9 | Pages: 14-17
DOI: https://doi.org/10.52403/ijhsr.20250903
Inflammatory Markers in Newly Diagnosed Diabetes Mellitus Type 2 (T2DM)
Kush Manna1, Dr. Jaya Jain2
1Ph.D. Scholar, Department of Biochemistry, Index Medical College, Hospital and Research Centre, Indore (M.P.)
2Professor, Department of Biochemistry, Index Medical College, Hospital and Research Centre, Indore (M.P.)
Corresponding Author: Kush Manna
ABSTRACT
Introduction: Diabetes Mellitus is a common metabolic syndrome in India, characterized by increased glucose levels and hyperglycemia due to modern lifestyle factors like junk food, lack of exercise, and heavy workload. Inflammatory markers like C-Reactive Protein, Superoxide Dismutase, and Malondialdehyde are disrupted, indicating the onset of Diabetes Mellitus type 2 (T2DM). This study aims to estimate these markers and correlate them with newly diagnosed Mellitus type 2 patients.
Aims & Objectives: The study aims to estimate inflammatory markers like hs-CRP, SOD, and MDA in newly diagnosed Diabetes Mellitus type 2 patients, and correlate these markers with the condition.
Materials & Methods: A study of 200 individuals was conducted to assess fasting blood sugar, HbA1c, highly sensitive C-Reactive Protein (hs-CRP), superoxide dismutase, and malondialdehyde levels, excluding those with surgical pancreas removal, cysts, or pancreatic tumours.
Discussion: A study found that newly diagnosed type 2 diabetes patients have higher HbA1c values and fasting blood sugar levels compared to healthy individuals. High-Sensitivity C-Reactive Protein (hs-CRP) and Superoxide Dismutase levels were also higher in these patients compared to the control group. Inflammatory markers showed a significant positive correlation, with only Superoxide Dismutase showing low values in the patients, while hs-CRP and MDA levels increased.
Conclusion & Summary: A study comparing 200 newly diagnosed Type 2 Diabetes Mellitus patients with 200 healthy controls found that they had significantly higher mean HbA1c levels and fasting blood sugar levels compared to the control group. The study also found significant differences in inflammatory and oxidative stress markers, with elevated high-sensitivity C-reactive protein (hs-CRP) and Malondialdehyde (MDA) levels in the diabetic group, and reduced Superoxide Dismutase (SOD) levels in T2DM patients. These findings suggest increased systemic inflammation and oxidative stress in T2DM patients, potentially contributing to early vascular and metabolic complications.
Key words: Diabetes Mellitus type 2, High Sensitivity C-Reactive Protein, Malondialdehyde, Superoxide Dismutase.