Year: 2025 | Month: August | Volume: 15 | Issue: 8 | Pages: 154-174
DOI: https://doi.org/10.52403/ijhsr.20250821
Pharmaceutical and Analytical Assessment of Jadamayadi Transdermal Pain Patch: An In Vitro Study on Development, Evaluation and optimization
Dr. Sudheera S1, Vivek Kumar2, Dr. Manojkumar K3
1Professor & HOD, Dept of Rasashastra and Bhaishajyakalpana, VPSV Ayurveda College, Kottakkal,
2UG Scholar, VPSV ayurveda college, Kottakkal, 3Professor & HOD, Dept of Kayachikitsa, Ashtamgam Ayurveda College, Palakkad
Corresponding Author: Dr. Sudheera S
ABSTRACT
The present study focuses on the pharmaceutical and analytical assessment of Jadamayadi transdermal pain patch through an in vitro approach for its development, evaluation, and optimization. Jadamayadi choorna, a classical Ayurvedic formulation known for its analgesic and anti-inflammatory properties, was incorporated into a transdermal patch system to enhance its therapeutic efficacy and patient compliance. Preparation of the transdermal patches polymer base by dissolving the selected polymer (HPMC and PVA) in a solvent like water or ethanol, and evaluated for physicochemical parameters including thickness, weight uniformity, folding endurance, moisture content, moisture uptake, drug content, and surface pH. The in vitro anti-arthritic activity is evaluated using the protein denaturation inhibition assay, phytochemicals analysis done by LC-MS technique. The formulation was optimized based on evaluation parameters to achieve desirable mechanical properties and sustained drug release. The study shows the anti-inflammatory, antiarthritic, analgesics property and the potential of Jadamayadi transdermal pain patch as a novel, effective, and non-invasive alternative for pain management, aligning traditional medicine with modern pharmaceutical technologies.
Key words: Anti-inflammatory, Anti-arthritic, Analgesics property, Pain patch