Year: 2025 | Month: February | Volume: 15 | Issue: 2 | Pages: 100-105
DOI: https://doi.org/10.52403/ijhsr.20250212
Nanotechnology-Future Prospects of Sperm-Driven Therapy in Oncology - A Review Article
Mohmed Fauzith. P1, Balaji. T1, Bala Krishnan. P2, John Felix. S.N2
1Pharm D Student, 2Pharm D Intern, Department of Clinical Pharmacy,
C L Baid Metha College of Pharmacy, Affiliated to “The Tamil Nadu Dr. MGR Medical University”, Chennai – 97, Tamil Nadu, India.
Corresponding Author: Mohmed Fauzith. P
ABSTRACT
Cancer is a major fatal disease worldwide, with millions of new cases and deaths each year. While treatments like chemotherapy and immunotherapy have saved many lives, they often come with severe side effects. A better solution being developed targeted drug delivery, which aims to deliver medication directly to cancer cells, which increasing the effectiveness of the treatment and reducing harmful side effects. One fascinating approach under development is sperm-loaded nanotherapy. This innovative method uses sperm cells as natural carriers for cancer drugs. Because sperm can move efficiently through the reproductive system, they’re ideal for targeting gynaecological cancers like cervical and ovarian tumors. By attaching anticancer drugs to sperm, researchers have created "spermbots" that navigate to tumors, deliver medication, and minimize harm to surrounding healthy tissues. This therapy takes advantage of nanotechnology to improve how drugs are delivered, including optimizing the size and shape of nanoparticles for better tumor penetration. While still experimental, this approach has shown promise in reducing cancer cell growth in lab studies. However, challenges like ensuring safety, improving drug loading efficiency, and addressing ethical concerns remain. Sperm-driven nanotherapy represents an exciting leap forward in cancer treatment, offering the potential for more precise, effective, and less toxic therapies. With further research, it could become a powerful tool not only for gynaecological cancers but also for other hard-to-reach tumors.
Key words: Cancer therapy, Nanotechnology, Targeted drug delivery, sperm-loaded nanotherapy, Enhanced permeability and retention (EPR), Spermbots.