Year: 2025 | Month: December | Volume: 15 | Issue: 12 | Pages: 67-72
DOI: https://doi.org/10.52403/ijhsr.20251208
Histomorphology Profile of Non-Neoplastic Polypoid Lesions of the Colon
Nupur A Kulkarni1, M W Pujari2
1Assistant Professor, Prakash Medical College and Research Centre, Uran-Ishwarpur (Islampur) Dist- Sangli, Maharashtra
2Assistant Professor, Prakash Medical College and Research Centre, Uran-Ishwarpur (Islampur) Dist- Sangli, Maharashtra
Corresponding Author: Dr. Nupur A Kulkarni
ABSTRACT
Introduction: A polyp is a mass protruding into the lumen of a hollow viscus. Colonic polyps may be sessile or pedunculated and are classified as neoplastic or non-neoplastic. While most are asymptomatic, some can cause bleeding, pain, obstruction, and have malignant potential. Histopathological evaluation is essential for early diagnosis and reducing colorectal cancer–related morbidity and mortality.
Material & Methods: This prospective study was conducted in the Department of Pathology, a tertiary care centre in Maharashtra, over two years (May 2013–April 2015). A total of 100 colonoscopic biopsy specimens were fixed in 10% buffered formalin, processed, and stained with Haematoxylin and Eosin. Standard tissue processing included dehydration in graded alcohol, clearing with xylene, paraffin embedding, microtome sectioning at 4 µm, slide mounting with glycerol egg albumin, and H&E staining. Microscopic examination was performed to classify and study histomorphology.
Results: Out of 15 non-neoplastic polypoidal lesions, females comprised 53.33% and males 46.66% (p = 0.9, not significant). Most cases were below 10 years of age (33.33%), decreasing in older groups (p = 0.54). Descending colon (33.33%) and rectum (26.66%) were the most affected sites (p = 0.25). Histopathologically, juvenile polyps predominated (53.33%), followed by hyperplastic (33.33%) and inflammatory polyps (13.33%) (p = 0.5).
Conclusion: Non-neoplastic colonic polypoidal lesions are predominantly benign, with juvenile polyps being the most common. The lesions occur mainly in younger age groups and slightly more in females, affecting the descending colon and rectum most frequently. Early histopathological evaluation facilitates accurate diagnosis, guides management, prevents complications, and may reduce colorectal morbidity, emphasizing the importance of timely detection and treatment.
Key words: Colo-rectal, Neoplasm, Polyp, Histopathological