Year: 2023 | Month: October | Volume: 13 | Issue: 10 | Pages: 377-383
DOI: https://doi.org/10.52403/ijhsr.20231049
Uncovering the Links Between Hematological and Biochemical Parameters in Chronic Kidney Disease: A Case-Control Study
Akanksha H1, Usha M2, Rashmi K3, Clement Wilfred D4
1Postgraduate, 2,3Assistant Professor, 4Professor,
Department of Pathology, M.S. Ramaiah Medical College, Bengaluru, India
Corresponding Author: Akanksha H
ABSTRACT
Aims and objectives- To evaluate the hematological and biochemical parameters in a group of CKD patients compared to normal subjects and to compare the changes in various parameters in different stages of CKD.
Material & Methods-This is a 10-month case control study on 150 CKD patients and 150 healthy controls at tertiary care hospital. A group of hematological parameters, such as haemoglobin (Hb), red blood cell count (RBC), mean corpuscular volume (MCV), haematocrit (PCV), total leucocyte count (TLC), platelet count (PL) and erythrocyte sedimentation rate (ESR) were measured. Also, peripheral smear examination was done. Biochemical parameters, such as creatinine, uric acid, Blood Urea Nitrogen (BUN), calcium (Ca), sodium (Na), potassium (K), chloride (Cl), phosphorus (P), C-Reactive Proteins (CRP), and random blood sugar (RBS) were compared with the controls and different stages of CKD.
Results- The mean age of presentation was 50 ± 10 years. The male to female ratio was 2.3:1. The mean hemoglobin was 9.5 ± 1 g/dl and mean creatinine was 4.5 ± 0.5 mg/dl. CKD patients exhibited significant drop in Hb, PCV, and RBC count as the disease stage progressed, indicating a worsening of anemia. TLC, differential neutrophil count, ESR, serum uric acid, creatinine, phosphorus, BUN, CRP, and RBS, were elevated while platelet count, and calcium were notably lower in patients compared to the controls (p < 0.001).
Conclusion-Through a meticulous analysis of hematological and biochemical parameters throughout the different stages of CKD, we can proactively manage and prevent complications, safeguarding the well-being of those afflicted.
Key words: Chronic kidney disease, Biochemical and hematological parameters, Creatinine, Hemoglobin.