Original Research Article
Year: 2022 | Month: January | Volume: 12 | Issue: 1 | Pages: 147-156
DOI: https://doi.org/10.52403/ijhsr.20220121
Duration of Type II DM, HbA1C Levels, TNF-α and IL-10 as Risk Factors for Level Charcot Joint Foot and Ankle in Type II DM Patients
Indra Rukmana Tri Pratistha1, Ketut Siki Kawiyana2, IGN Wien Aryana2
1Resident, Orthopedic and Traumatology Department, Faculty of Medicine Udayana University, RSUP. Sanglah General Hospital, Bali.
2Consultant, Orthopedic and Traumatology Department, Faculty of Medicine Udayana University, Sanglah General Hospital, Denpasar, Bali.
Corresponding Author: Indra Rukmana Tri Pratistha
ABSTRACT
Introduction: Type II Diabetes Mellitus has complications including disorders of the musculoskeletal system or what is often called diabetic charcot joint or charcot neuroarthropathy. Various risk factors are thought to increase the incidence of Charcot joint foot and ankle. Various studies have been made to assess these risk factors with the aim of reducing the occurrence of these complications.
Material and Methods: The study used an analytical observational design with a case study and control approach to determine whether Type II DM II ≥ 10 years, HbA1c levels II ≥ 7%, TNF-α levels II ≥ 1.0 ng/L and IL-10 levels ≤ 255 pg/mL as factors. risk of Charcot joint foot and ankle in Type II DM patients. Where the sample involves 24 case groups and 24 control groups. Then a descriptive analysis was performed, bivariate inferential analysis using the chi-square test and an assessment of the risk factor odds ratio (OR). Then multivariate analysis was performed to assess the strength of the influence of risk factors using logistic regression test
Results: There is a significant difference between Type II DM II ≥ 10 years, HbA1c levels II ≥ 7%, TNF-α levels II ≥ 1.0 ng/L, and IL-10 levels ≤ 255 pg/mL which are risk factors for the occurrence of charcot joint foot and ankle in Type II DM patients. The duration of type II DM II ≥ 10 years had the strongest relationship while IL-10 ≤ 255 pg/mL had the weakest relationship for the occurrence of Charcot joint foot and ankle in Type II DM patients.
Conclusion: Increased duration of Type II DM, HbA1c level and TNF-α level above certain level and low IL-10 amount are risk factor for Charcot joint foot and ankle in Type II DM patients, with the duration of type II DM being the strongest risk factor.
Key words: Diabetes mellitus type II, charcot joint foot and ankle, risk factors.