Original Research Article
Year: 2022 | Month: November | Volume: 12 | Issue: 11 | Pages: 86-93
DOI: https://doi.org/10.52403/ijhsr.20221113
Effect of Hyperglycemia on Impairment of Calcium Metabolism in T2DM
Kawalpreet Kaur1, Gurpreet Kaur Gill1, Ravi Kumar Dhawan2
1Department of Medical Lab Sciences, Khalsa College of Pharmacy & Technology, Amritsar, Punjab (India)
2Department of Pharmacology, Khalsa College of Pharmacy, Amritsar, Punjab (India)
Corresponding Author: Dr. Gurpreet Kaur Gill
ABSTRACT
Background: T2DM or type 2 diabetes mellitus is mostly related to the growing incidence of reduction in bone mineral density with increased porosity and susceptibility to fractures. Diabetes mellitus eventually compromise bone quality through production of advanced glycation products and misalignment of collagen fibrils, thereby culminating in reduction of bone strength. The underlying cellular mechanisms are related to suppression of osteoblast-induced bone formation and calcium accretion, as well as enhancement of osteoclast- induced bone resorption.
Objectives: The aim of the present study was to evaluate the effect of high glucose level on the impairment of calcium metabolism in diabetes mellitus patients and to study the inter- relationship between diabetes mellitus and calcium metabolism. The linked association between them would be helpful to support public health policy markers and practioners.
Materials and Methods: Total 100 samples were collected from Government Civil Hospital, Lopoke (Amritsar) with age group of 35-60 years having duration of diabetes more than 5 years. Blood and urine samples were analysed for biochemical parameters such as serum fasting glucose, alkaline phosphatase (ALP), albumin, vitamin D, phosphorus and calcium. Urine samples were also analysed to examine the excretion of phosphorus and calcium.
Results: Decreased levels of serum calcium, albumin, vitamin D in serum along with elevated urinary calcium were observed in type 2 diabetic patients.
Conclusion: From the study it has revealed that in the diabetic patients the calcium metabolism has been affected by the hyperglycemic state of the body. Hence, it is well established that effect of hyperglycemia on calcium metabolism is a risk factor for the development of osteoporosis in diabetic patients.
Key words: Diabetes mellitus, Insulin, Osteoporosis, Calcium, Phosphorus, Vitamin D.