Original Research Article
Year: 2022 | Month: November | Volume: 12 | Issue: 11 | Pages: 12-17
DOI: https://doi.org/10.52403/ijhsr.20221103
Effects of Smoking on Hepatic and Renal Biomarkers among Smokers in Brazzaville
Landry Martial Miguel1, Adèle Tsieta1, Choupette Ravelle Dobhat-Doukakini1, Donatien Moukassa1, Ange Antoine Abena1,2
1Clinical And Molecular Biochemistry Unit, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of Congo
2Dénis Sassou N'Guesso University, Kintélé, Republic of Congo
Corresponding Author: Landry Martial Miguel
ABSTRACT
Background : Exposure to tobacco has serious consequences on many organs such as the liver and kidneys.
Objective. This study aimed to determine the effect of cigarette smoking on serum concentrations of uric acid, creatinine, and transaminases (AST and ALT).
Materials And Methods : A cross-sectional study was conducted during the period from July to november 2018, in Brazzaville (Republic of Congo). A total of 100 subjects were included, on the basis of inclusion criteria randomly allocated, 50 smokers and 50 non-smokers. The smokers were divided into three groups according to the intensity and duration of smoking (light smokers, moderate smokers and heavy smokers). The average age was 35.86 ± 11.65 and 31.88 ± 8.92, respectively for non-smokers and smokers. A pre-established questionnaire allowed the collection of demographic and clinical data. Urine samples were collected to verify cigarette smoking status. The biochemical assays were carried out by spectrophotometry, on the serum obtained after centrifugation of venous blood collected on a dry tube, using commercial kits. The average age and weight of smokers were lower than those of non-smokers. The levels of uric acid, creatinine and transaminases were significantly elevated in the groups of smokers, depending on the intensity and duration of smoking compared to the group of non-smokers.
Key words: smokers, tobacco, uric acid creatinine, transaminases, Brazzaville.