Review Article
Year: 2020 | Month: June | Volume: 10 | Issue: 6 | Pages: 149-156
Critical Review of Extreme Effects of Exposome/ Interaction between Genetics and Environment on Hearing Disorders Reclassified
Sokolo Gedikondele J1, Longo-Mbenza B1,2,3,4, Matanda Nzanza R1, Mvitu Muaka M1, Mambueni Thamba C1, Nkodila Natuhoyila A4, Tukadila Kabangi HA4, Longo Longo G4
1University of Kinshasa, Faculty of Medicine, Democratic Republic of Congo
2Walter Sisulu University, MTHATHA, South Africa
3University President Joseph KASA-VUBU, Democratic Republic of Congo
4Lomo University of Research, Kinshasa-Limete, Democratic Republic of Congo
Corresponding Author: Nkodila Natuhoyila A
ABSTRACT
This article has critically reviewed the literature's information on the deleterious effects of the exposome on the reclassification of auditory disorders. Thus, a theoretical framework was proposed including the conceptual model and hypotheses to be tested in the process of hearing impairment. The exposome describes the interactions between genetics, chronobiology, diet, risk behaviour, infections, urbanization, physical environment, active smoking, epigenetics, health system, biometrics and reclassification of the host man's auditory disorders. Conclusion: With the progress of science, the genesis and development of hearing disorders (mixed or isolated by conduction and perception) are currently elucidated by the exposome (integration of the environmental harmful exposure set, infections, and oxidative stress during the evolution of age.
Key words: Exposome, Genetics, Environment, and Deafness.