Original Research Article
Year: 2020 | Month: January | Volume: 10 | Issue: 1 | Pages: 127-134
Effect of Dacryodes Edulis Pulp Oil Treatment on Restraint Stress-Induced Behavioral and Biochemical Alterations in Mice
Landry Martial Miguel1, Didier Gesril N’jilo1, Ruphin Bertrand Bolanga1, Etienne Mokondjimobe1, Donatien Moukassa1,2, Benjamin Longo-Mbenza3, Ange Antoine Abena1, Gabriel Muanda Mabiala3,4, Herman Ndilu Muanda3,4
1Faculty of Health Sciences, Marien NGOUABI University, BP 69 Brazzaville,
2Edith Lucie BONGO ONDIMBA General Hospital, Oyo,
3LOMO University of Research,
4PHARMALAB DRC Sarl,
University of Kinshasa, RDC
Corresponding Author: Landry Martial Miguel
ABSTRACT
Background: A stressful stimulus is a crucial determinant of health and disease. Antidepressants are used to manage stress and their related effects. The present study was designed to investigate the effect of D. edulis pulp oil in restraint stress-induced behavioral and biochemical alterations in mice.
Methods: Animals were immobilized for a period of 24 hr. D. edulis pulp oil (5 and 10 ml/kg) was administered 24 hr after the acute immobilized stress. Various behavioral tests parameters for anxiety (open field test, elevated plus Maze test), cognitive performance (Morris water maze) were assessed, followed by biochemical assessments (catalase, malondialdehyde level, nitrite and protein) subsequently.
Results: 14 days D. edulis treatment in a dose of 5 and 10 ml/kg significantly attenuated restraint stress-induced behavioral (improved locomotor activity, and antianxiety like effect) and oxidative damage as compared to control (restraint stress).
Conclusion: Present study showed important neuroprotective effect of D. edulis pulp oil against acute restraint stress induced behavioral and biochemical modifications.
Key words: Dacryodes edulis; stress; behavioral; biochemical; mice.